Stress Induced Diabetes
Vaishnav Priti Baludas, Kadam Kavita Shivaji, Kalunkhe
Amruta Dadasaheb, Pagar Swati Aappasaheb*, Musmade Deepak Sitaram
SDSPM’s, Nandkumar Shinde College of Pharmacy,
Vaijapur, Dist - Aurangabad, M.S, India – 423701.
*Corresponding Author E-mail: swati.pagar2210@gmail.com
ABSTRACT:
Many evidences suggested that stressful
experience might affect diabetes. The estimate of the actual number of diabetes
in India is around 40 million. This means India actually has the highest number
of diabetic’s patient of any one country in entire world. No doubt, one of the
natural element of life i.e. Stress is a major contributor to the diabetes.
Stress can bring many unexpected changes in the blood sugar level; this could
trigger symptoms associated with diabetes. Some retrospective human studies
have suggested that the stress can participate in Type-1 diabetes, animal
studies have shown that stress can cause Type-1 diabetes. impaired glucose
tolerance and metabolic disease, however human studies have shown that stress
can stimulate hyperglycaemia, insulin resistance. In contrast more
consistentevidence support the role of stress in Type-2 diabetes. In recent
year the complexities of the relationship between stress and diabetes have
become well known but have been less well researched. Some studies have
suggested that stressful experience may affect the onset and the metabolic
control of diabetes, but finding have often been inconclusive. In this article
we reviewed some of this research going on to consider how stress might affect
the diabetes and physiological mechanism through which this may occurs and
their preventions and management.
KEYWORDS: Stress, Diabetes, Hyperglycemia, Insulin resistance,
impaired glucose tolerance, physical activity, diet.
INTRODUCTION:
What
is Stress?
Simply
out, Stress is a state of emotional strain or tension that occurs when we feel
that we can't cope with pressure. Stress is a feeling of emotional or physical
tension, it can come from any event or thought that make you feel frustrated,
angry or nervous. But whenever stress starts for a long time, it may harm your
health. Stress weather physical stress or mental stress has been proven to instigate
change in blood sugar level which for people with diabetes can problematic1.
DIABETES
MELLITUS:
Diabetes
is chronic condition. Diabetes mellitus (DM) is one of the most common non -
communicable disease in the world. According to the International Diabetes
federation estimate, around 415 million people had diabetes mellitus in 2015
and this number is expected to be rise to 642 million by 2040.
India
with 69.1 million people is estimated to have the second-highest number of case
diabetes mellitus (DM) in the world after china in 20152. DM is
continue to increase as a result of rapid cultural and social changes. Which
include aging populations, increasing urbanization, dietary changes, reduced
the physical activity and unhealthy behaviour3,4.
The
'International Diabetes Federation' has also stressed the importance of
integrating physiological care in the management of the DM5. Stress
may lead to deterioration of glycaemic control through its effect on the
neuroendocrine system6.
Role
of Stress in Diabetes:
Stress
is a potential contributor to chronic hyperglycaemia in diabetes. Stress has
long been shown to have major effect on metabolic activity. Energy
metabolization is a primary result of the fight or flight response. Stress
stimulate the release of various hormone, which can result in elevated blood
glucose level. If you are experiencing stress or feeling threatened, your body
reacts. This is called a fight or flight response. This response elevated your
hormone level and causes your cell to fire, during this response, your body
release adrenaline and cortisol into your blood stream and your respiratory
rates increases. Your body direct blood to muscle and limbs allowing you to
fight the situations. Your body may not be able to process the glucose released
by your firing nerve cell if you have diabetes. If you cannot converts glucose
into energy, itgets build up into the blood stream. This cause your blood
glucose level to rise.
The
stress hormone like cortisol and adrenaline make harder for insulin to work
properly, known as insulin resistance. As energy can't get into your cells,
your body sugar level increases in your blood stream. Researchers think that
high level of stress hormone might stop insulin producing cell in the pancreas
from working properly and reduce the amount of insulin they make, in turn, this
might contribute to the development of Type-2 diabetes. Stressful experience
have been implicated in the onset of diabetes in individual already predisposed
to developing disease. As early as the beginning researchers have been
discussing the potential link between diabetes and stress since the 17thcentury7.
More
recent research suggests that people with depression, anxiety, stress have
higher risks of developing type-2diabetes8. Mooy et.al. Demonstrates
an association between stressful experience and the diagnosis of type 2
diabetes. Thernlund at al. suggested that negative stressful experience in the
first 2 years of life may increase the risks of developing type 1 diabetes in
children, other factor such as family problems, behavioural problems were also
implicated.Swedish study indicates that there was no association between
stressful event and the onset of type 1diabetes9.
People
who experience depression, anxiety, stress or combination of these conditions
are at higher risks of developing diabetes10. Stress affect many
lifestyle factors, high level of stress may cause a person to engage in
unhealthy lifestyle habits. This lifestyle habits can increase a person's risk
of developing diabetes.
Stress
can activate the hypothalamic pituitary adrenal axis and the sympathetic
nervous system. This can cause hormonal changes, like higher cortisol hormonal
level and lower sex hormone levels. The level of this hormone affect insulin
level. Cortisol is commonly known as the stress hormone. It can also stimulates
the production of glucose in the body and rises a person's blood sugar. Stress
may also affect the immune system.
Surwit,
Feiglos and Scovem have recently summerised the mechanism by which
environmental, emotional or physical stress can affect the glucose metabolism.
They reviewed the relationship between the Central Nervous System, Autonomic
Nervous System and Hypothalamic adrenal cortical axis in controling the glucose
metabolism. The Autonomic nervous system is intimately involved in the regulation
of carbohydrate metabolism. The effect of autonomic nervous system on insulin
is both facilitatory and inhibitory. Branches of the right vagus nerve
innervates the pancreatic islets and the stimulation of beta cells of
pancreatic islets facilitate the release of insulin, conversely insulin
secretion is inhibited by stimulation of the sympathetic nervous system. This
sympathetic and parasympathetic innervation of pancreas modulate the insulin
secretion in normal regulation of carbohydrates metabolism. Neurogenic
stimulation of the hypothalamic pituitary adrenal axis leads to the secretion
of cortisol from the adrenal cortex, which elevates blood glucose and impaired
glucose tolerance. Stress induced release of growth hormone can also cause
insulin resistance and beta endorphins which can suppress insulin secretion and
elevated glucose levels (Guillemin 1978)11.
How
stress affect the blood sugar level?
The
blood sugar level are controlled mainly by two groups of hormones. The first
group of hormone reduce blood sugar but Insulin is the only member of this
group. The Second group of hormones called counter- regulatory hormone, opposes
the action of insulin and increase the blood sugar. (eg. Cortisol, Adrenaline
and Noradrenaline).
Two types of stress can
change blood sugar levels:
· Physical stress
· Mental or emotional stress
each
type of stress affect blood sugar levels differently. Physical stress generally
cause blood sugar level to increase.
Physical
stress include:
· Illness
· Surgery
· Injury
Physical
or emotional stress has mixed effect depending on type of diabetes you have.
Type
1 diabetes:
Mental
stress can increase or decrease blood sugar level.
Type
2 diabetes:
Mental
stress generally increase blood sugar level. It is very important to detect
high stress level on patients, since the blood sugar will come down only if
stress is relieved or controlled.12
Stress,
Neuroendocrine Axis and Glucocorticoids:
It
is known that stress activates hypothalamus-pituitary- adrenal axis. The brain
circuits that initiate and maintain stress response are located in the
hypothalamus, which include paraventricular nuclei, locus ceruleus and the
central sympathetic nervous system13,14. Stress activates the
paraventricular nucleus (hypothalamus) in the brain and stimulates endocrine
and neural mechanisms leading to an increase in the concentrations of stress
hormones viz. glucocorticoids and catecholamines. Precisely, the activated paraventricular
nucleus neurons secrete corticotropin releasing hormone (CRH) which regulates
the adrenocorticotropic hormone (ACTH) release from the anterior pituitary.
ACTH acts on the adrenal cortex to release glucocorticoids15,16.
These neuroendocrine changes seem to lack habituation and possibly there was an
abnormal hypothalamo- pituitary- adrenal axis (HPA axis) activation in response
to repeated stress17. In addition, sympathetic nervous system is
activated which releases norepinephrine direct to the circulation and
epinephrine from the adrenal medulla. It is demonstrated that glucocorticoids
and catecholamines act synergistically during stress.18
ACTH;
adrenocorticotrophic hormone. CRH: corticotrophin releasing hormone LC/NE:
locusceruleus norepinephrine system; PVN: paraventricular nucleus32.
Catecholamine’s
act transiently during the initial exposure to stress and at later stages would
be accompanied by the secretion of glucocorticoids. Glucocorticoids are
generally referred to as stress hormones [19] as their secretion
will be high under stressful conditions. Glucocorticoids elicit their action by
binding to glucocorticoid receptors (GRs) that regulate various physiological
functions viz., inflammation, gluconeogenesis and adipocyte differentiation
etc.20 Upon binding with ligand, it is dimerized and translocated
into nucleus where it binds to glucocorticoids (GCs) response elements (GREs)
and bring out the gene expression of the target genes.
The
mechanisms of stress induced alterations in glucose metabolism leading to
hyperglycemia are also elucidated which involve the changes in different
pathways. The chronic stress is reported to cause hypermetabolism characterized
by enhanced glycolysis, gluconeogenesis, altered glucose uptake and reduced glycogenesis.
Persistent stress predispose to the development of chronic illness accompanied
by the metabolic dysregulation.21,22
Figure
1: Hypothalamo-pitutary-Adrenal Axis.
Fig
2: Neuroendocrine response to stress:
Lifestyle
and Prevention of Stress Induced Diabetes:
Stress
is a part and parcel of our modern, fast-paced lives. Following a healthy
lifestyle with adequate exercise, correct diet and regular sleeping hours will
keep one physically and mentally fit to face any stressful situation that may arise
in one’s life. It is particularly important that a person with diabetes learns
how to manage stress, since stress can wreak havoc with the management of
diabetes. A healthy social life, taking time out to relax with friends and
family is vital in reducing stress levels, thereby reducing the risk of
developing diabetes and helping people with diabetes take control of their
condition. We have seen many patients who were able to reduce their dose of
drugs and several cases like the one described previously, who were able to
completely stop all anti-diabetic medications. Find out if stress is the cause
of your diabetes, and if yes, please start stress management measures today.
You cannot avoid stress but you can certainly manage it!
Tips
on Coping with Stress23
Sometimes,
the symptoms of stress are subtle and you may not notice them. Stress can take
a toll on your mental and emotional well-being, and it can also impact your
physical health. Recognizing the symptoms can help you identify stress and take
steps to manage it.
How
To Reduce Your Stress Levels:
It’s
possible to lessen or limit the stressors in your life. Here are a few things
that you can do to manage the effects of different forms of stress.
Reducing
mental stress:
Meditating
can help remove negative thoughts and allow your mind to relax. Consider
starting each morning with a 15-minute meditation. This will set the tone for
the rest of your day.24
Reducing
emotional stress:
If
you find yourself in an unwanted emotional state, take five minutes to be by
yourself. Remove yourself from your current environment. Find a quiet space to
focus on your breathing. Put your hand on your belly, and feel it rise and
fall. Inhale deep breaths, and exhale slowly and loudly. This will slow your
heartbeat down, and help bring you back to a stable emotional state. This act
of cantering yourself may improve how you deal with whatever is causing the
stress.
Reducing
physical stress:25
Adding
yoga to your daily routine can provide both physical activity and meditation at
the same time. Practicing yoga can lower your blood pressure, too. Whether its
yoga or another form of exercise, you should aim for 30 minutes of
cardiovascular exercise per day. You can do 10 minutes of exercise when you
wake up, 10 minutes in the afternoon, and 10 minutes before you go to sleep.
Reducing
family stress:26
If
you’re feeling overwhelmed by family obligations, remember that it’s OK to say
no. Your family will understand if you can’t make it to all events. If your
stress stems from not seeing your family as often as you’d like, consider
having a family fun night weekly or biweekly. You can play board games or
participate in outdoor activities. This can include hiking, swimming, or
singing up for a fun run together.
Reducing
work stress:
Stress
issues at work can come home with you. Talk to your supervisor if you’re having
a hard time at work. There may be options to alleviate or work through any
issues you may have. If that doesn’t help, you may want to consider
transferring to a different department or even finding new job altogether.
Although stress levels elevate when looking for a new job, you may find it
settles down with a different position better suited for your skills and
personality.
Tea and diabetes:
Tea is one of the nation’s favourite
drinks and research suggests it’s also a healthy drink. Tea brings a number of
health benefits including improving insulin sensitivity.
Research suggests the following benefits
may be enjoyed from tea:
· Improving insulin sensitivity
· Maintaining healthy blood pressure
· Preventing blood clots
· Reducing risk of cardiovascular disease
· Reducing risks of developing type 2
diabetes
· Reducing risks of developing cancer
CONCLUSION:
Many
research suggests that stress have a negative impact on your body. Whenever we
think of the couses of diabetes, we usually think about hereditary factors (family
history), overeating or lack of exercise leading to obesity as the most common
cause of diabetes. At that time we often tend to forget about important cause
of diabetes i.e stress. It is true that high level of stress leads to unhealthy
lifestyle habits, which can in turn, increase person's risk of developing
diabetes. Stress is a situation that almost everyone faces on a daily basis.
Stress has been linked to several ailments chief of which are depression and
diabetes. Stress is not a direct cause of diabetes but stress can cause a
fluctuation in blood sugar in people with diabetes. Although there is no
concrete evidence to substantially prove that stress (emotional) is responsible
for diabetes, many healthcare professionals believe that diabetes is case as a
result of the changes or rise hormonal level as a result of stress. In this
article we have discussed the impact of stress on blood sugar level. Long term
stressors have a adverse effects on blood sugar level. The impact of stress on
blood sugar varies from one patient to another. Medical studies have shown that
physiological or mental stress can elevate blood glucose levels in individual
with type 2 diabetes and majority of type 1 diabetes. However glucose level may
drops in some people with type 1 diabetes.
It
is clear that emotional stress (fear, anxiety, anger, excitement, tension) and
physiological stress (illness, pain, infection, injury) cause the body to
secrete stress hormones into blood stream. For those without diabetes, the
stress induced blood sugar rise is followed by an increase in insulin
secretion, so the blood sugar rise is modest and temporary. For those which
have diabetes, however stress can causes a significant and prolonged increase
in blood sugar level. So it is very important to be aware that repeated episode
of stress can cause serious changes in blood sugar level making difficult for
diabetics to control the condition.If you are stressed for longer periods of
time your sugar level will keep building in blood.so regular exercise and
relaxation techniques like yoga, meditation and breathing exercise can help you
to control blood sugar level during stress condition.When you live with
diabetes, what you eat and how much you exercise make a big difference to your
health. So get smart about food you choose and the way you move. You will not
only get your blood sugar level under control, but you will cut your chances of
having a heart attack and stroke, too. So you have to control the stress level
then you will come down your blood sugar level.
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Received on 26.08.2020
Modified on 30.11.2020
Accepted on 22.02.2021
©Asian Pharma Press All Right Reserved
Asian J. Res. Pharm. Sci. 2021; 11(2):145-150.
DOI: 10.52711/2231-5659.2021-11-2-9